Assessment of Anti-bacterial Activity of (E)-2-(Naphthalen-1-yldiazenyl) Malononitrile Against Pathogens Bacteria.

Authors

  • Hagar Husssien Nawara Department of Chemistry, Faculty of Education (Al-Zintan), Al-Zintan University, Libya Author
  • Khaled Abdusalam Department of Botany, Alassaba'a Faculty of Science, Gharyan University, Libya Author
  • Hajer Mohamed Elgherianic Libyan Centre for Biotechnology Research Author

DOI:

https://doi.org/10.65405/28gdne61

Keywords:

Azo compounds; Malononitrile; Antibacterial activity; MRSA, Escherichia coli.

Abstract

(E)-2-(naphthalen-1-yldiazenyl) malononitrile (NDMN) was synthesized via a diazotization–coupling reaction and evaluated for its antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. The compound showed strong, concentration-dependent antibacterial activity, with significantly higher efficacy against MRSA than E. coli, as confirmed by disc diffusion, MIC, and MBC assays. These results suggest that NDMN is a promising synthetic antimicrobial agent, particularly against Gram-positive resistant bacteria, and merits further biological and toxicity investigations.

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References

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Published

2025-12-06

Issue

Vol. 10 No. 38 (2025): Comprehensive Journal of Science

Section

المقالات

License

Copyright (c) 2025 Comprehensive Journal of Science

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Assessment of Anti-bacterial Activity of (E)-2-(Naphthalen-1-yldiazenyl) Malononitrile Against Pathogens Bacteria. (2025). Comprehensive Journal of Science, 10(38), 2306-2314. https://doi.org/10.65405/28gdne61